Novel encoding methods for DNA-templated chemical libraries

作者：Li, Gang; Zheng, Wenlu; Liu, Ying; Li, Xiaoyu^*

来源：Current Opinion in Chemical Biology, 2015, 26: 25-33.

DOI：10.1016/j.cbpa.2015.01.004

• PEPTIDE NUCLEIC-ACID
• IN-VITRO SELECTION
• DEFINED SYNTHETIC-POLYMERS
• SMALL-MOLECULE EVOLUTION
• PROTEIN-BINDING AGENTS
• DRUG DISCOVERY
• COMBINATORIAL CHEMISTRY
• ORGANIC-SYNTHESIS
• STRAND-DISPLACEMENT
• MICROARRAYS

Among various types of DNA-encoded chemical libraries, DNA-templated library takes advantage of the sequence-specificity of DNA hybridization, enabling not only highly effective DNA-templated chemical reactions, but also high fidelity in library encoding. This brief review summarizes recent advances that have been made on the encoding strategies for DNA-templated libraries, and it also highlights their respective advantages and limitations for the preparation of DNA-encoded libraries.

• 出版日期2015-6
• 单位北京大学深圳研究生院; 北京大学