Acquired Bartter-like syndrome association with netilmicin therapy in an extremely low birth weight infant

作者：Sandal Gonca^*; Akbay Senay; Ozen Metehan

来源：Renal Failure, 2014, 36(1): 123-125.

DOI：10.3109/0886022X.2013.832861

• Acquired Bartter-like syndrome
• netilmicin
• preterm infant

Aminoglycosides are commonly used antibiotics with excellent renal parenchymal penetration. Their clinical effectiveness is counter balanced with the risk of renal toxicity, which develops in a dose-dependent fashion. Aminoglycoside-induced renal tubular dysfunction could result in diffuse damage or manifest as a Fanconi-like syndrome, Bartter-like syndrome (BLS), or distal renal tubular acidosis. 1-4 Although tubulopathy associated with amikacin and gentamicin was reported in adults and rarely children, to the best of our knowledge, netilmicin-associated BLS neither in adults nor in children has been reported in the literature. We here report a 30-week, 770 g male preterm infant who developed BLS just after netilmicin treatment for neonatal sepsis and recovered 6 weeks after the drug cessation.

• 出版日期2014-2