Apoptosis in the anucleate platelet

作者：Leytin Valery^*

来源：Blood Reviews, 2012, 26(2): 51-63.

DOI：10.1016/j.blre.2011.10.002

• Platelet apoptosis
• Extrinsic and intrinsic apoptosis pathways
• Apoptosis triggers and markers
• PAR-1, GPIIbIIIa, GPIb alpha receptors
• Mitochodrial control
• Shear stress
• Cyclosporin A
• Intravenous immunoglobulin
• Eptifibatide (Integrilin)
• Tirofiban (Aggrastat)

For many years, programmed cell death, known as apoptosis, was attributed exclusively to nucleated cells. Currently, however, apoptosis is also well-documented in anucleate platelets. This review describes extrinsic and intrinsic pathways of apoptosis in nucleated cells and in platelets, platelet apoptosis induced by multiple chemical stimuli and shear stresses, markers of platelet apoptosis, mitochodrial control of platelet apoptosis, and apoptosis mediated by platelet surface receptors PAR-1, GPIIbIIIa and GPIb alpha. In addition, this review presents data on platelet apoptosis provoked by aging of platelets in vitro during platelet storage, platelet apoptosis in pathological settings in humans and animal models, and inhibition of platelet apoptosis by cyclosporin A, intravenous immunoglobulin and GPIIbIIIa antagonist drugs.

• 出版日期2012-3