A direct and stereospecific approach to the synthesis of alpha-glycosyl thiols

作者:Dere Ravindra T; Wang Yingxi; Zhu Xiangming*
来源:Organic and Biomolecular Chemistry, 2008, 6(12): 2061-2063.
DOI:10.1039/b804536d

摘要

A new simple method for the synthesis of alpha-glycosyl thiols is described. Ring-opening of 1,6-anhydrosugars with commercially available bis(trimethylsilyl) sulfide under the action of catalytic amounts of TMSOTf smoothly afforded alpha-glycosyl thiols in very high yields and in a stereospecific way.