A convenient strategy to 2,4,5-triaryl and 2-alkyl-4,5-diaryl oxazole derivatives through silver-mediated oxidative C-O cross coupling/cyclization

作者：Sarkar Rajib; Mukhopadhyay Chhanda^*

来源：Tetrahedron Letters, 2015, 56(25): 3872-3876.

DOI：10.1016/j.tetlet.2015.04.103

• Oxidative cross coupling
• Silver carbonate
• Primary amines
• 2,4,5-Triaryl oxazoles
• 2-Alkyl-4,5-diaryl oxazoles

This is a silver(I) mediated C-alpha(sp(3))-H activation of primary amines followed by oxidative C-O cross coupling/cyclization for the construction of 2,4,5-triaryl and 2-alkyl-4,5-diaryl oxazole derivatives. The protocol has been successfully utilized to synthesize the oxazole derivatives in good to excellent yields. In this oxidative coupling, the silver species after the reaction was successfully re-synthesized and reused with almost a similar activity.

• 出版日期2015-6-17