Autophagy mediates transporter associated with antigen processing-independent presentation of viral epitopes through MHC class I pathway

作者：Tey Siok Keen; Khanna Rajiv^*

来源：Blood, 2012, 120(5): 994-1004.

DOI：10.1182/blood-2012-01-402404

The endogenous presentation of the majority of viral epitopes through MHC class I pathway is strictly dependent on the transporter associated with antigen processing (TAP) complex, which transfers the peptide products of proteasomal degradation into the endoplasmic reticulum. A small number of epitopes can be presented through the TAP-independent pathway, the precise mechanism for which remains largely unresolved. Here we show that TAP-independent presentation can be mediated by autophagy and that this process uses the vacuolar pathway and not the conventional secretory pathway. After macroautophagy, the antigen is processed through a proteasome-independent pathway, and the peptide epitopes are loaded within the autophagolysosomal compartment in a process facilitated by the relative acid stability of the peptide-MHC interaction. Despite bypassing much of the conventional MHC class I pathway, the autophagy-mediated pathway generates the same epitope as that generated through the conventional pathway and thus may have a role in circumventing viral immune evasion strategies that primarily target the conventional pathway. (Blood. 2012;120(5):994-1004)

• 出版日期2012-8-2
• 单位河北医科大学