科研之友
微信
新浪微博
Facebook
分享链接
摘要
Objective: It is unclear whether atlas-based parcellation is suitable in aging cohorts because age-related brain changes confound the performance of automatic methods. We assessed atlas-based parcellation of the prefrontal lobe in an aging population using visual assessment and volumetric and spatial concordance. Methods: We used an atlas-based approach to parcellate brain MR images of 90 non-demented healthy adults, aged 72.7 +/- 0.7 years, and assessed performance. Results: Volumetric assessment showed that both single-atlas- and multi-atlas-based methods performed acceptably (intraclass correlation coefficient [ICC], 0.74-0.76). Spatial overlap measurements showed that multi-atlas (dice coefficient [DC], 0.84) offered an improvement over the single-atlas (DC, 0.75-0.78) approach. Visual assessment also showed that multi-atlas outperformed single atlas and identified an additional post-processing step of cerebrospinal fluid removal, enhancing concordance (intraclass correlation coefficient, 0.86; DC, 0.89). Conclusions: Atlas-based parcellation performed reasonably well in the aging population. Rigorous performance assessment aided method refinement and emphasizes the importance of age matching and post-processing. Further work is required in more varied subjects.
- 出版日期2013-4
