An Association of Elevated Levels of Alkaline Phosphatase and Gamma-Glutamyl Transpeptidase with Acute Chollangitis

作者：Tomizawa Minoru^*; Shinozaki Fuminobu; Hasegawa Rumiko; Togawa Akira; Shirai Yoshinori; Ichiki Noboru; Motoyoshi Yasufumi; Sugiyama Takao; Yamamoto Shigenori; Sueishi Makoto

来源：Hepato-Gastroenterology, 2014, 61(130): 291-295.

DOI：10.5754/hge13582

• Receiver operating characteristic
• Area under the curve

Background/Aims: The early diagnosis of acute cholangitis (AC) is critical for appropriate treatment. Methodology: Patient records from April 2008 to December 2012 were retrospectively analyzed. Data on white blood cell count and levels of C-reactive protein, total-bilirubin, alkaline phosphatase (ALP), aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transpeptidase (gamma-GTP) were collected from AC patients on the day they underwent endoscopic retrograde cholangiopancreatography (ERCP) for diagnosis and treatment. Data were collected 3 months before ERCP to analyze the rate of change of these variables. Receiver operating characteristics curve analysis was performed. Results: We enrolled 63 patients with AC and 65 patients with non-AC. The threshold values of ALP and gamma-GTP were 1.09 and 1.30, respectively. Conclusions: 450 (IU/L) and 100 (IU/L), respectively were thresholds of ALP and gamma-GTP on the day of ERCP. 1.09 and 1.30, respectively were thresholds of ALP and gamma-GTP rates of change for the diagnosis of AC.

• 出版日期2014-4