科研之友
微信
新浪微博
Facebook
分享链接
摘要
Background: Information on the association between.-glutamyltransferase (GGT) and the incidence of atrial fibrillation (AF) is scarce. We evaluated the association between GGT and AF incidence, and the interaction between GGT and obesity on developing AF in a large population-based cohort. Methods: We evaluated 266,550 individuals (mean age, 53 +/- 11; men, 48.4%) who underwent the national insurance health checkup between 2004 and 2008. Subjects were categorized in accordance with quartiles of GGT levels (range: Q1, 0-15U/L; Q2, 16-22 U/L; Q3, 23-38 U/L; Q4, >= 39 U/L). The association between GGT levels and AF incidence was analyzed by using multivariable Cox proportional-hazards regression models. Results: During amedian of 8 years' follow-up, 5034 individuals (1.9%) were newly diagnosedwith AF. The crude AF incidence gradually increased with increases in GGT level (1.9, 2.5, 2.8, and 3.1 per 1000 person-years in the Q1, Q2, Q3, and Q4 GGT groups, respectively; p for trend <0.001). In the multivariable Cox proportional hazard models, GGT level showed a dose-response relationship with AF incidence. The subjectswith the highest quartile of GGT levels had a significantly higher risk of AF (hazard ratio [HR], 1.31; 95% confidence interval [CI], 1.18-1.45; p <0.001). When the analysis was stratified by body mass index (BMI), GGT level showed good discrimination for AF incidence only in the non-obese population (BMI < 25 kg/m(2)), and not in the obese population (BMI >= 25 kg/m(2); p interaction < 0.001). Conclusions: In this large population-based study, elevated GGT level showed a significant association with increased risk of AF, especially in a non-obese population.
- 出版日期2017-10-15
