Development of a PIXE analysis method for the determination of the biopersistence of SiC and TiC nanoparticles in rat lungs

作者：Lozano Omar^*; Mejia Jorge; Masereel Bernard; Toussaint Olivier; Lison Dominique; Lucas Stephane

来源：Nanotoxicology, 2012, 6(3): 263-271.

DOI：10.3109/17435390.2011.572301

• Biopersistance
• nanoparticles
• characterization

With the advent of nanoparticles produced in high quantities and employed in products or processes, the need to evaluate their potential toxicological effects is necessary. For this purpose, biopersistence studies are needed to assess the possible effects of nanoparticles in parallel with a proper characterization. The insoluble character of many nanomaterials makes traditional chemical analytical methods unapplicable for the ex-vivo measurements of their concentration in organs. Ion beam-based techniques such as Particle-Induced X-ray Emission (PIXE) can solve this difficulty. We illustrate that by the measurement of biopersistence of SiC and TiC nanoparticles instilled in rats lungs and investigated over a 60-day time span. The results can be obtained within minutes and the limits of detection are within ppm levels.

• 出版日期2012-5