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摘要
BACKGROUND AND PURPOSEThe aim of this study is to explore the possible changed cerebral white matter regions in patients with temporal lobe epilepsy (TLE) using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS). @@@ METHODSTwenty TLE patients and 22 age- and gender-matched normal controls were included in this study. Voxel-wise analyses of multiple diffusion metrics, including fractional anisotropy (FA) and mean diffusivity (MD) were performed with TBSS. @@@ RESULTSTLE patients exhibited significantly reduced FA in widespread white matter regions including bilateral limbic circuit, corpus callosum, thalamus, internal/external capsule, temporooccipital connections, frontotemporal connections; increase of MD was exhibited significantly almost in the left hemisphere. A significant decrease in global FA integrity was shown in epilepsy subjects compared to healthy controls. Furthermore, it exhibited a significant positive correlation between the disease duration and MD of whole brain. @@@ CONCLUSIONSTLE is associated with widespread abnormalities in cerebral white matter tracts and these changes may have important clinical consequences.
- 出版日期2015-5
- 单位广州中医药大学第一附属医院; 华南师范大学; 南方医科大学
