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摘要
The purpose of this study was to develop a noninvasive imaging test of pancreatic exocrine function. Methods: In this pilot study, 5 healthy volunteers underwent two 60-min dynamic C-11-acetate PET studies, one before and one after intravenous secretin administration. Kinetic analysis of the pancreas was performed using a 1-compartment model and an image-derived input function. From summed images, standardized uptake values were measured from the pancreas and the liver, and the pancreas-to-liver ratio was computed. Results: The baseline k(1) and k(2) data for all 5 volunteers were consistent. After secretin stimulation, the k(1) and k(2) significantly increased (paired t test P = 0.046 and P = 0.023, respectively). In the summed PET images, the pancreas-to-liver ratio decreased (P = 0.037). Increased C-11-acetate activity was observed in the duodenum after secretin stimulation consistent with secretin-induced secretion. Conclusion: C-11-acetate PET studies with secretin stimulation show potential as a noninvasive method for assessing pancreatic exocrine function.
- 出版日期2014-7
