Neurological disease-associated autoantibodies against an unknown protein encoded by a RES4-22 homologous gene

作者：Amin M; Uhlig HH; Kamprad M; Karbe J; Osman AA; Grahmann F; Hummelsheim H; Mothes T^*

来源：Scandinavian Journal of Immunology, 2001, 53(2): 204-208.

DOI：10.1046/j.1365-3083.2001.00839.x

Screening a human small intestinal library with human serum yielded a clone which encoded a protein res4-22 the gene of which was highly homologous to a recently described gene located in the Huntington's disease locus. Autoantibodies against res4-22 (anti-res4-22). mainly of the immunoglobulin (Ig)A type, were detected in patients with neurological disorders at a higher frequency (18.4%) than in healthy blood donors (8.0%). In neurological patients with cerebral ischaemia anti-res4-22 was found significantly more often (47.4%) than in the total group of neurological patients. Anti-res4-22 positive sera showed significantly more frequently myelin staining in cerebellum and nerve sections than anti-res4-22 negative sera. Our findings demonstrate a new species of human autoantibodies against a newly described protein the function of which is still unknown.

• 出版日期2001-2