Aromatic Nitrogen Donors for Efficient Copper(I)-NHC CuAAC under Reductant-Free Conditions

作者：Teyssot Marie Laure; Nauton Lionel; Canet Jean Louis; Cisnetti Federico; Chevry Aurelien; Gautier Arnaud^*

来源：European Journal of Organic Chemistry, 2010, 2010(18): 3507-3515.

DOI：10.1002/ejoc.201000046

• Click chemistry
• CuAAC
• Heterocycles
• Carbenes
• Copper

Copper(I) -catalysed azide-alkyne cycloaddition (CuAAC) has been successfully conducted under reductant-free conditions. The catalytic system consisted of a combination of a copper(I)-N-heterocyclic carbene complex and aromatic N-donors. The catalyst is stable and can be stored, thus rendering the reaction valuable for routine use.

• 出版日期2010-6