Association of Cytokine Gene Polymorphisms (IL6, IL10, TNF-alpha, TGF-beta and IFN-gamma) and Graves%26apos; Disease in Turkish Population

作者：Kutluturk Faruk^*; Yarman Sema; Sarvan Fatma Oguz; Kekik Cigdem

来源：ENDOCRINE METABOLIC %26 IMMUNE DISORDERS-DRUG TARGETS, 2013, 13(2): 163-167.

DOI：10.2174/18715303113139990001

• Cytokine
• graves%26apos
• disease
• interferon
• interleukin
• polymorphism
• transforming growth factor
• tumour necrosis factor

Introduction: Cytokines play a crucial role in the pathogenesis of autoimmune thyroid disease, and recent studies have demonstrated an association between cytokine gene polymorphisms and Graves%26apos; Disease (GD) in different ethnic groups. The aim of the present study was to investigate the relationship of interleukin-6 (IL-6), IL-10, tumor necrosis factor-alpha (TNF-alpha), transforming growth factor-beta (TGF-beta), and interferon-gamma (INF-gamma) gene polymorphisms in the development of GD in Turkish population. %26lt;br%26gt;Material and Methods: A total of 224 subjects were included in the study comprising of 100 patients with GD (70 female, 30 male; mean age, 43.9 +/- 13.8 years) and 124 healthy subjects (81 female, 43 male); mean age, 37.8 +/- 10.2 years) without antithyroid autoantibodies or family history of autoimmune disorders. Genotyping was conducted by using PCR and sequence-specific primers. %26lt;br%26gt;Results: Statistical analysis showed a significant association between high TNF-alpha -308GA and IL-6 -174CC gene polymorphisms in patients with GD compared to control subjects (p=0.016, p=0.044, respectively). However, no significant differences were observed between GD and control subjects for IL-10, TGF-beta, and INF-gamma gene polymorphisms. %26lt;br%26gt;Conclusion: TNF-alpha-308GA and IL-6 -174CC gene polymorphisms are involved in susceptibility to GD in Turkish population. The polymorphism hypothesis in pro-inflammatory cytokines might be involved in predisposition to GD.

• 出版日期2013-6