An unusual synthesis of tetrahydrobenzo[f]isoquinolines

作者：Pratap Ramendra; Raghunandan Resmi; Maulik P R; Ram Vishnu Ji^*

来源：Tetrahedron Letters, 2007, 48(45): 7982-7985.

DOI：10.1016/j.tetlet.2007.09.059

• 2-Oxo-4-(piperidin-1-yl)-5,6-dihydro-2H-benzo[h]-chromene-3-carbonitrile s
• ring transformation
• benzo[f]-isoquinoline

A facile and short synthesis of 2-oxo-4-sec-amino-2,3,5,6-tetrahydrobenzo[f]isoquinoline-1-carbonitriles has been delineated through base catalyzed ring transformation of 5,6-dihydro-2-oxo-4-sec-amino-2H-benzo[h]chromene-3-carbonitrile by cyanoacetamide in excellent yields.

• 出版日期2007-11-5