Aerosol droplet delivery of mesoporous silica nanoparticles: A strategy for respiratory-based therapeutics

作者：Li Xueting; Xue Min; Raabe Otto G; Aaron Holly L; Eisen Ellen A; Evans James E; Hayes Fred A; Inaga Sumire; Tagmount Abderrahmane; Takeuchi Minoru; Vulpe Chris; Zink Jeffrey I; Ri**ud Subhash H; Pinkerton Kent E^*

来源：Nanomedicine: Nanotechnology, Biology and Medicine , 2015, 11(6): 1377-1385.

DOI：10.1016/j.nano.2015.03.007

• Mesoporous silica nanoparticles
• Aerosol droplets
• Respiratory tract

A highly versatile nanoplatform that couples mesoporous silica nanoparticles (MSNs) with an aerosol technology to achieve direct nanoscale delivery to the respiratory tract is described. This novel method can deposit MSN nanoparticles throughout the entire respiratory tract, including nasal, tracheobronchial and pulmonary regions using a water-based aerosol. This delivery method was successfully tested in mice by inhalation. The MSN nanoparticles used have the potential for carrying and delivering therapeutic agents to highly specific target sites of the respiratory tract. The approach provides a critical foundation for developing therapeutic treatment protocols for a wide range of diseases where aerosol delivery to the respiratory system would be desirable.

• 出版日期2015-8