Design and synthesis of some novel hydrazide, 1,2-dihydropyridine, chromene derivatives carrying biologically active sulfone moieties with potential anticancer activity

作者：Bashandy Mahmoud S; Al Said Mansour S; Al Qasoumi Saleh I; Ghorab Mostafa M^*

来源：Drug Research, 2011, 61(9): 521-526.

• Anticancer activity
• Breast cancer cell line
• Chromene derivatives
• 1,2-Dihydropyridine
• Hydrazide derivatives
• Sulfone derivatives

This paper describes the synthesis of some novel sulfones having biologically active hydrazides (4-9, 22, 23, 26 and 27), hydrazonoyl cyanide (24), 1,2-dihydropyridines (16-21), chromene (28) and benzochromene (29) moieties starting with 1-[4-(piperidin-1-ylsulfonyl)phenyl]-ethanone 1. The structures of the the newly synthesized compounds were confirmed by elemental analysis, IR, (1)H NMR and (13)C NMR. ALL the newly synthesized compounds were evaluated for their in vitro anticancer activity against breast cancer cell line (MCF7).

• 出版日期2011