Acetylated cashew gum-based nanoparticles for transdermal delivery of diclofenac diethyl amine

作者：Lopes Dias Savia Francisca; Nogueira Silvania Siqueira; Dourado Flaviane de Franca; Guimaraes Maria Adelaide; de Oliveira Pitombeira Nadia Aline; Gobbo Graciely Gomides; Primo Fernando Lucas; Monteiro de Paula Regina Celia; Andrade Feitosa Judith Pessoa; Tedesco Antonio Claudio; Cunha Nunes Livio Cesar; Souza Almeida Leite Jose Roberto; da Silva Durcilene Alves^*

来源：Carbohydrate Polymers, 2016, 143: 254-261.

DOI：10.1016/j.carbpol.2016.02.004

• Nanoparticles
• Acetylated cashew gum
• Diclofenac diethyl amine
• Cytotoxicity
• Transdermal delivery

Nanoprecipitation and dialysis methods were employed to obtain nanoparticles (NPs) of acetylated cashew gum (ACG). NPs synthesized by dialysis showed greater average size compared to those synthesized by nanoprecipitation, but they presented improved stability and yield. NPs were loaded with diclofenac diethylamine and the efficiency of the drug incorporation was over 60% for both methods, for an ACG: NP a weight ratio of 10:1. The cytotoxicity assay demonstrated that the NPs had no significant effect on the cell viability, verifying their biocompatibility. The release profile for the diclofenac diethylamine associated with the ACG-NPs showed a more controlled release compared to the free drug and a Fickian diffusion mechanism was observed. Transdermal permeation reached 90% penetration of the drug.

• 出版日期2016-6-5