Natural killer cell heterogeneity: cellular dysfunction and significance in HIV-1 immuno-pathogenesis

作者：Ansari A Wahid; Ahmad Fareed; Meyer Olson Dirk; Kamarulzaman Adeeba; Jacobs Roland; Schmidt Reinhold E

来源：Cellular and Molecular Life Sciences, 2015, 72(16): 3037-3049.

DOI：10.1007/s00018-015-1911-5

• Innate immunity
• CD56 dim and bright
• Granzyme B
• Antibody-dependent cellular cytotoxicity
• Highly active antiretroviral therapy

Natural killer (NK) cells are innate immune effectors that provide first line of defence against viruses. Human NK cells are heterogeneous in nature, and their functions rely on a dynamic balance between germ-line-encoded activating and inhibitory receptors. HIV-1 infection results in altered NK cell receptor repertoire and impaired effector functions including the ability to lyse virus-infected cells and secretion of antiviral cytokine IFN-gamma. Over the last decade, additional NK cell subset-specific molecules have been identified, leading to emergence of a more complex cellular diversity than previously thought. Herein, we discuss NK cell subset redistribution, altered receptor repertoire and influence of interaction of polymorphic leucocyte antigen (HLA) and killer cell immunoglobulin-like receptors (KIR) on HIV-1 disease progression.

• 出版日期2015-8