An Efficient Synthesis and Antimicrobial Studies of Bioactive 4H-1,4-Benzothiazine and Their Sulfone Derivatives

作者：Gautam Naveen; Dixit Yogesh; Dixit Rahul; Gupta Sudesh Kumar; Gautam Dinesh Chand^*

来源：Phosphorus, Sulfur, and Silicon and the Related Elements, 2013, 188(8): 1127-1136.

DOI：10.1080/10426507.2012.740703

• 4H-1,4-benzothiazine
• heterocycles
• sulfones and antimicrobial activity

4H-1,4-benzothiazines were prepared by condensation followed by oxidative cyclization of substituted 2-aminobenzenethiols with -diketones in dimethylsulfoxide. On refluxing with 30% hydrogen peroxide in glacial acetic acid, 4H-1,4-benzothiazines yielded 4H-1,4-benzothiazine-1,1-dioxides. Structural evaluation has been done by spectral and elemental analysis. All the synthesized compounds were evaluated for their antibacterial and antifungal activity and all these have shown moderate to high activity against the test microbes. Supplementary materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfer, and Silicon and the Related Elements for the following free supplemental files: Additional text, figures and tables.

• 出版日期2013-8-1