Association between Glu504Lys Polymorphism of ALDH2 Gene and Cancer Risk: A Meta-Analysis

作者：Cai, Qiang; Wu, Jian; Cai, Qu; Chen, Er-Zhen; Jiang, Zhao-Yan^*

来源：PLos One, 2015, 10(2): e0117173.

DOI：10.1371/journal.pone.0117173

• SQUAMOUS-CELL CARCINOMA
• ALDEHYDE DEHYDROGENASE 2
• ALCOHOL-METABOLIZING ENZYMES
• ESOPHAGEAL CANCER
• COLORECTAL-CANCER
• HEPATOCELLULAR-CARCINOMA
• GLU487LYS POLYMORPHISM
• MYOCARDIAL-INFARCTION
• PANCREATIC-CANCER
• GASTRIC-CANCER

Background @@@ The association of the aldehyde dehydrogenases-2 (ALDH2) Glu504Lys polymorphism (also named Glu487Lys, or rs671) and cancers has been investigated. This meta-analysis aims to comprehensively assess the influence of this polymorphism on the overall cancer risk. @@@ Methods @@@ Eligible publications were retrieved according to inclusion/exclusion criteria and the data were analyzed using the Review Manager software (V5.2). @@@ Results @@@ A meta-analysis based on 51 case-control studies consisting of 16774 cases and 32060 controls was performed to evaluate the association between the ALDH2 Glu504Lys polymorphism and cancer risk. The comparison of genotypes Lys+ (Lys/Lys and Lys/Glu) with Glu/Glu yielded a significant 20% increased cancer risk (OR = 1.20, 95%CI: 1.03-1.39, P = 0.02, I-2 = 92%). Subgroup analysis by cancer type indicated a significantly increased UADT cancer risk (OR = 1.39, 95%CI: 1.11-1.73, P = 0.004, I-2 = 94%) in individuals with the Lys+ genotypes. Subgroup analysis by country indicated that individuals from Japan with the Lys+ genotypes had a significant 38% increased cancer risk (OR = 1.38, 95%CI: 1.12-1.71, P = 0.003, I-2 = 93%). @@@ Conclusions @@@ Our results indicated that the ALDH2 Glu504Lys polymorphism is a susceptible loci associated with overall cancers, especially esophageal cancer and among Japanese population.

• 出版日期2015-2-13
• 单位上海交通大学; 上海市闵行区中心医院