Direct Noncatalytic Electrophilic Trifluoroacetylation of Electron-Rich Pyrazoles

作者：Yarmoliuk Dmytro V; Arkhipov Viatcheslav V; Stambirskyi Maksym V; Dmytriv Yurii V; Shishkin Oleg V; Tolmachev Andrei A; Mykhailiuk Pavel K^*

来源：Synthesis (Germany), 2014, 46(9): 1254-1260.

DOI：10.1055/s-0033-1340840

• trifluoromethyl group
• trifluoroacetyl group
• fluorine
• pyrazole
• building blocks

Electron-rich N-substituted pyrazoles smoothly reacted with trifluoroacetic anhydride in pyridine to form the corresponding trifluoromethyl ketones in good yields.

• 出版日期2014-5