Negative life events and corticotropin-releasing-hormone receptor 1 gene in recurrent major depressive disorder

作者：Liu Zhongchun; Liu Wanhong; Yao Lihua; Yang Can; Xiao Ling; Wan Qirong; Gao Kai; Wang Huiling; Zhu Fan; Wang Gaohua; Xiao Zheman^*

来源：Scientific Reports, 2013, 3(1): 1548-1548.

DOI：10.1038/srep01548

Major depressive disorder (MDD) is a long-term, recurrent condition that often takes a chronic course. It seems imperative that research should be focused on gaining a better understanding of what predicts recurrent MDD. As a major mediator of the stress response, corticotropin-releasing-hormone receptor 1 (CRHR1) has been demonstrated to be an important contributor to the pathogenesis of MDD. In this study, we show a significant increase in the G-allele (rs242939) of the CRHR1 gene in the recurrent MDD group compared with the control group, and an overrepresentation of G-G-T hyplotype of the CRHR1 gene in recurrent MDD. We also demonstrate the interaction of the CRHR1 gene and negative life events in recurrent MDD. These results suggest that the CRHR1 gene could modify the susceptibility to developing recurrent MDD following negative life events in adulthood.

• 出版日期2013-3-26
• 单位武汉大学