An efficient one-step method for the synthesis of 2-(indolizin-2-yl)benzimidazoles from quinoxalinones and alpha-picoline via a novel rearrangement

作者：Mamedov Vakhid A^*; Saifina Dina F; Gubaidullin Aidar T; Saifina Alina F; Rizvanov Il'dar Kh

来源：Tetrahedron Letters, 2008, 49(43): 6231-6233.

DOI：10.1016/j.tetlet.2008.08.032

• quinoxalin-2-one
• benzimidazole
• alpha-picoline
• ring contraction
• rearrangement
• indolizinylbenzimidazoles
• (1)H NMR data
• X-ray diffraction analysis

A highly efficient one-step and versatile method for the synthesis of 2-(indolizin-2-yl)benzimidazoles has been developed on the basis of the novel ring contraction of 3-arylchloromethyl- and alkylchloromethylquinoxalin-2-ones with alpha-picoline.

• 出版日期2008-10-20