Novel application of HKUST-1 metal-organic framework as antifungal: Biological tests and physicochemical characterizations

作者：Chiericatti Carolina; Carlos Basilico Juan; Zapata Basilico Maria L; Manuel Zamaro Juan

来源：Microporous and Mesoporous Materials, 2012, 162: 60-63.

DOI：10.1016/j.micromeso.2012.06.012

• Metal-organic framework
• HKUST-1
• Anti fungal activity
• Copper release

The HKUST-1 metal-organic framework (MOF) was successfully applied as a biocidal material against representative yeast and mold. The synthesized MOF showed a strong antifungal effect against Saccharomyces cerevisiae for which the growth was completely inhibited, whereas the growth of Geotrichum candidum was reduced from 6.16 to 1.29 CFU mL(-1). The antifungal action was related to copper ions released into the culture medium due to a progressive degradation of the crystalline structure of the material that involved the formation of surface extra-framework Cu(I). This study shows the potential of using copper-based metal-organic frameworks for a controlled release of biologically active copper ions.

• 出版日期2012-11-1