Gene structure and chromosome mapping of mouse transcription elongation factor S-II (Tcea1)

作者：Ito T; Seldin MF; Taketo MM; Kubo T; Natori S^*

来源：Gene, 2000, 244(1-2): 55-63.

DOI：10.1016/S0378-1119(00)00007-X

• chromosome mapping
• gene structure
• processed pseudogene
• Tcea1
• Tcea1-ps1
• transcript elongation

We report the organization and chromosome localization of the mouse transcription elongation factor S-II gene (Tcea1). This gene was found to be a single copy gene consisting of 10 exons spanning approximately 30 kb. Its organization was the same as those of the mouse testis-specific S-II gene (Tcea2) and Xenopus general S-II gene (xTFIIS.oA), but different from that of the human S-II gene family. We also identified a processed pseudogene (Tcea1-ps1) with a sequence highly homologous to those of S-II cDNAs but containing a translation termination codon within its open reading frame. Linkage analysis showed that Tcea1 and Tcea1-ps1 are mapped on mouse chromosomes 1 and 15, respectively. Relationships between Tcea1 and S-II cDNAs isolated so far are discussed.

• 出版日期2000-2-22