Developing a new algorithm for first and second trimester preeclampsia screening in twin pregnancies

作者：Maymon Ron^*; Trahtenherts Alla; Svirsky Ran; Melcer Yaakov; Madar Shapiro Liora; Klog Esther; Meiri Hamutal; Cuckle Howard

来源：Hypertension in Pregnancy, 2017, 36(1): 108-115.

DOI：10.1080/10641955.2016.1242605

• PP13
• PlGF
• PAPP-A
• Doppler UTPI
• MAP

Objectives: Construct a new preeclampsia predicting algorithm in twins.Methods: Twins sampled at 10-13 and 16-20 gestational weeks and their marker values were log transformed into multiples of the gestation-specific medians (MoMs) for singletons and entered into a new logistic regression model with/without prior risk factors.Results: The cohort included 9 PE (18 samples) and 96 unaffected cases (175 samples) twin pregnant women. The algorithm constructed of PlGF, PAPP-A, PP13, Doppler UTPI, and MAP with prior risk factors generated an area under the curve of 0.918, 75% detection rate for 10% false-positive rate.Conclusions: The algorithm effectively forecasted twin risk to develop PE.

• 出版日期2017-2