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摘要
We describe the versatile and concise total synthesis of all stereoisomers of tarchonanthuslactone from (R)- or (S)-3-hydroxybutyrate via eight steps. The key steps of the synthesis include a highly diastereoselective chelation-controlled Mukaiyama aldol reaction of a p-methoxybenzyl-protected aldehyde and a Yamaguchi lactonization of a -hydroxy-trans-,-unsaturated carboxylic acid.
- 出版日期2015-9
- 单位北京大学深圳研究生院; 江西科技师范大学
