Association of toll-like receptor 2 gene polymorphisms with normal tension glaucoma

作者：Nakamura Jutaro; Meguro Akira^*; Ota Masao; Nomura Eiichi; Nishide Tadayuki; Kashiwagi Kenji; Mabuchi Fumihiko; Iijima Hiroyuki; Kawase Kazuhide; Yamamoto Tetsuya; Nakamura Makoto; Negi Akira; Sagara Takeshi; Nishida Teruo; Inatani Masaru; Tanihara Hidenobu; Aihara Makoto; Araie Makoto; Fukuchi Takeo; Abe Haruki; Higashide Tomomi; Sugiyama Kazuhisa; Kanamoto Takashi; Kiuchi Yoshiaki; Iwase Aiko; Ohno Shigeaki; Inoko Hidetoshi; Mizuki Nobuhisa

来源：Molecular Vision, 2009, 15(306-07): 2905-2910.

Purpose: Toll-like receptor 2 (TLR2) is a transmembrane receptor that mediates immune responses to exogenous and endogenous ligands, and interacts with heat-shock proteins, which are reportedly involved in normal tension glaucoma (NTG). We investigated whether TLR2 polymorphisms are associated with NTG.
Methods: 200 Japanese patients with NTG and 128 healthy Japanese controls were recruited. We genotyped five single-nucleotide polymorphisms (SNPs) in the TLR2 gene and assessed the allele and haplotype diversities between cases and controls for all SNPs.
Results: No significant differences in the frequency of TLR2 alleles and haplotypes in the NTG cases were detected, compared with the controls.
Conclusions: Our study showed no evidence for an association between TLR2 polymorphisms and NTG. TLR2 polymorphisms may not play an important role in NTG pathogenesis in the Japanese population.

• 出版日期2009-12-26