Age-related changes in natural killer cell receptors from childhood through old age

作者:Almeida Oliveira Aline*; Smith Carvalho Monique; Porto Luis Cristovao; Cardoso Oliveira Juliana; Ribeiro Aline dos Santos; Falcao Rosangela Rosa; Abdelhay Eliana; Bouzas Luis Fernando; Santos Thuler Luiz Claudio; Ornellas Maria Helena; Diamond Hilda Rachel
来源:Human Immunology, 2011, 72(4): 319-329.
DOI:10.1016/j.humimm.2011.01.009

摘要

Most studies on natural killer (NK) cells and aging have focused on overall cell numbers and global cytotoxic activity. NM cell functions are controlled by surface receptors belonging to three major families: killer cell immunoglobulin-like receptors (KIRs), natural cytotoxicity receptors (NCRs), and C-type lectins. The expression of these receptors was investigated from childhood through old age in T, NKT- and NM cells and also in the CD56(dim) (cytotoxic) and CD56(bright) (responsible for cytokine production) NM cell subsets. A decrease in the expression of activating receptors (NKp30 and NKp46) was observed in NM cells in elderly individuals. KIR expression was increased only in the CD56(bright) subset. Children presented similar results regarding expression of NKp30 and KIR, but not NKp46. NKG2D expression was decreased in T cells of elderly subjects. Analysis of KIR genotype revealed that KIR2DL5 and KIR2DS3 were significantly associated with old age. Cytotoxic activity was preserved from childhood through old age, suggesting that the increase of the absolute number of CD56(dim), observed in elderly, may represent a compensatory mechanism for the receptor expression alterations. This initial study provides the framework for more focused studies of this subject, which are necessary to determine whether the changing balance of NK receptor expression may influence susceptibility to infectious, inflammatory, and neoplastic diseases.

  • 出版日期2011-4