NEW DIHYDROAGAROFURANOID SESQUITERPENES FROM CELASTRUS ANGULATUS

作者:Liu Jiang yun*; Tan Bei bei; Gong Xue long; Xu Qiong ming; Sun Xiao fei; Cai Pei lie; Yang Shi lin
来源:Heterocycles, 2012, 85(3): 689-696.
DOI:10.3987/COM-12-12420

摘要

Three new highly esterified beta-dihydroagarofuran sesquiterpenes (1-3) were isolated from the root barks of Celastrus angulatus Max. together with eight (4-11) known ones. The new compounds were identified as 1 beta-picolinoyloxy-2 beta,6 alpha-diacetoxy-8 beta,13-diisobutanoyloxy-9 alpha-benzoyloxy-4 alpha-hydroxy-beta-dihydro- agarofuran (I), 1 beta-picolinoyloxy-2 beta,6 alpha-diacetoxy-8 beta,13-diisobutanoyloxy-9 alpha-furanoyloxy-4 alpha-hydroxy-beta-dihydroagarofuran (2), and 1 beta,6 alpha-diacetoxy-2 beta-nicotinoyloxy-8 beta,13-diisobutanoyloxy-9 alpha-benzoyloxy-4 alpha-hydroxy-beta-dihydro- agarofuran (3) on the basis of spectroscopic methods. Compounds 1-11 were all possessed cytotoxic activities against three human tumor cell lines by MTT assay.