MR Elastography of the Liver and the Spleen Using a Piezoelectric Driver, Single-Shot Wave-Field Acquisition, and Multifrequency Dual Parameter Reconstruction

作者：Hirsch Sebastian; Guo Jing; Reiter Rolf; Papazoglou Sebastian; Kroencke Thomas; Braun Juergen; Sack Ingolf^*

来源：Magnetic Resonance in Medicine, 2014, 71(1): 267-277.

DOI：10.1002/mrm.24674

• 3D multifrequency MRE
• least-squares inversion
• piezoelectric driver
• shear waves
• complex shear modulus
• loss tangent
• liver
• portal hypertension

Purpose: Viscoelastic properties of the liver are sensitive to fibrosis. This study proposes several modifications to existing magnetic resonance elastography (MRE) techniques to improve the accuracy of abdominal MRE.
Methods: The proposed method comprises the following steps: (i) wave generation by a nonmagnetic, piezoelectric driver suitable for integration into the patient table, (ii) fast single-shot 3D wave-field acquisition at four drive frequencies between 30 and 60 Hz, and (iii) single-step postprocessing by a novel multifrequency dual parameter inversion of the wave equation. The method is tested in phantoms, healthy volunteers, and patients with portal hypertension and ascites.
Results: Spatial maps of magnitude and phase of the complex shear modulus were acquired within 6-8 min. These maps are not subject to bias from inversion-related artifacts known from classic MRE. The spatially averaged modulus for healthy liver was 1.44 +/- 0.23 kPa with phi=0.492 +/- 0.064. Both parameters were significantly higher in the spleen (2.29 +/- 0.97 kPa, P=0.015 and 0.749 +/- 0.144, P=6.58.10(-5), respectively).
Conclusion: The proposed method provides abdominal images of viscoelasticity in a short time with spatial resolution comparable to conventional MR images and improved quality without being compromised by ascites. The new setup allows for the integration of abdominal MRE into the clinical workflow. Magn Reson Med 71:267-277, 2014.

• 出版日期2014-1
• 单位河北医科大学