科研之友
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摘要
A continuous process strategy has been developed for the preparation of alpha-thio-beta-chloroacrylamides, a class of highly versatile synthetic intermediates. Flow platforms to generate the alpha-chloroamide and alpha-thioamide precursors were successfully adopted, progressing from the previously employed batch chemistry, and in both instances afford a readily scalable methodology. The implementation of the key alpha-thio-beta-chloroacrylamide casade as a continuous flow reaction on a multi-gram scale is described, while the tuneable nature of the cascade, facilitated by continuous processing, is highlighted by selective generation of established intermediates and by products.
- 出版日期2016-11-24
