科研之友
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摘要
Gamma delta (?d) ? cells are non-conventional T lymphocyte effectors that can interact with and eradicate tumour cells. Several data demonstrate that these T cells, which are implicated in the first line of defence against pathogens, have anti-tumour activity against many cancers and suggest that ?d ? cell-mediated immunotherapy is feasible and might induce objective tumour responses. Due to the importance of ?d ? lymphocytes in the induction and control of immunity, a complete understanding of their biology is crucial for the development of a potent cancer immunotherapy. This review discusses recent advances in ?d ? basic research and data from clinical trials on the use of ?d ? cells in the treatment of different cancers. It analyses how this knowledge might be applied to develop new strategies for the clinical manipulation and the potentiation of ?d ? lymphocyte activity in cancer immunotherapy.
- 出版日期2013-1
