Abnormal neural activities in first-episode, treatment-naive, short-illness-duration, and treatment-response patients with major depressive disorder: A resting-state fMRI study

作者：Guo, Wen-bin; Liu, Feng; Xue, Zhi-min; Yu, Yan; Ma, Chao-qiong; Tan, Chang-lian; Sun, Xue-li; Chen, Jin-dong; Liu, Zhe-ning; Xiao, Chang-qing; Chen, Hua-fu^*; Zhao, Jing-ping

来源：Journal of Affective Disorders, 2011, 135(1-3): 326-331.

DOI：10.1016/j.jad.2011.06.048

• Major depressive disorder
• Functional magnetic resonance imaging
• Resting state
• Regional homogeneity

Background: Abnormality of limbic-cortical networks was postulated in depression. Using a regional homogeneity (ReHo) approach, we explored the regional homogeneity (ReHo) of the brain regions in patients with first-episode, treatment-naive, short-illness-duration, and treatment-response depression in resting state to test the abnormality hypothesis of limbic-cortical networks in major depressive disorder (MDD).
Methods: Seventeen patients with treatment-response MOD and 17 gender-, age-, and education-matched healthy subjects participated in the resting-state fMRI scans.
Results:
1. The MDD group showed a significant lower ReHo in the left cerebellum posterior lobe, the right fusiform gyrus, the left parahippocampal gyrus, and the right postcentral gyrus compared with healthy subjects (p < 0.05, corrected).
2. Relative to healthy subjects, a significant higher ReHo was found in the right inferior temporal gyrus in the MDD group (p < 0.05, corrected).
Conclusions: Our findings suggested the abnormality of limbic-cortical networks in first-episode, treatment-naive, short-illness-duration, and treatment-response MDD patients, and added an expanding literature to the abnormality hypothesis of limbic-cortical networks in MDD.

• 出版日期2011-12
• 单位四川大学; 电子科技大学; 广西医科大学; 中南大学; 上海市精神卫生中心