A chiral pyrrolidine-pyrazole catalyst for the enantioselective Michael addition of carbonyls to nitroolefins

作者:Chandrasekhar Srivari*; Kumar Togapur Pavan; Haribabu Kothapalli; Reddy Chada Raji; Kumar Chitumalla Ramesh
来源:Tetrahedron: Asymmetry , 2011, 22(6): 697-702.
DOI:10.1016/j.tetasy.2011.04.010

摘要

An enantioselective Michael reaction of carbonyl compounds to nitroolefins has been accomplished using a novel chiral pyrrolidine-pyrazole catalyst. This newly prepared catalyst was found to be very effective in providing good yields as well as good diastereo- and enantio-selectivities. The mechanism of the reaction has also been substantiated by mass spectral studies.

  • 出版日期2011-3-30