Elucidating the protein cold-adaptation: Investigation of the parameters enhancing protein psychrophilicity

作者：Jahandideh Mina; Barkooie Seyyed Mohsen Hosseini; Jahandideh Samad; Abdolmaleki Parviz^*; Movahedi Mohammad Mehdi; Hoseini Somayyeh; Asadabadi Ebrahim Barzegari; Jouni Fatemeh Javani; Karami Zahra; Firoozabadi Nader Hodjati

来源：Journal of Theoretical Biology, 2008, 255(1): 113-118.

DOI：10.1016/j.jtbi.2008.07.034

• Psychrophilic protein
• Structural analysis
• Substitution preference
• Systematic analysis

To investigate the role of the critical parameters in adaptation of proteins to low temperatures, a comparative systematic analysis was performed. Several parameters were proposed to have contribution to cold adaptation of proteins. Among proposed parameters, total values of residual Structure states, secondary structure states and oligomeric states were alike in both psychrophilic and mesophilic proteins. In addition, our results provided new quantitative information about the trends in the substitution preference of Ile, Phe, Tyr, Lys, Arg, His, Glu and Leu with most of amino acids and substitution avoidance of Gly, Thr and Ala with most of amino acids. These findings would help future efforts propose a strategy for designing psychrophilic proteins.

• 出版日期2008-11-7