Association of SNP and STR polymorphisms of insulin-like growth factor 2 receptor (IGF2R) gene with milk traits in Holstein-Friesian cows

作者：Dux Marta; Muranowicz Magdalena; Siadkowska Eulalia; Robakowska Hyzorek Dagmara; Flisikowski Krzysztof; Bagnicka Emilia; Zwierzchowski Lech^*

来源：Journal of Dairy Research, 2018, 85(2): 138-141.

DOI：10.1017/S0022029918000110

• TG(n) microsatellite
• A/G transition
• genetic marker
• association
• dairy traits

The objective of the study reported in this Research Communication was to investigate the association of polymorphisms in the insulin-like growth factor receptor 2 (IGF2R) gene with milk traits in 283 Polish Holstein-Friesian (PHF) cows from the IGAB PAS farm in Jastrzebiec. IGF2R regulates the availability of biologically active IGF2 which is considered as a genetic marker for milk or meat production in farm animals. Two novel genetic polymorphisms were identified in the bovine IGF2R gene: a polymorphic TG-repeat in intron 23 (g.72389 (TG)15-67), and a g.72479 G>A SNP RFLP-Styl in exon 24. The following milk traits were investigated: milk yield, protein and fat yield, SCC and lactose content. To determine the influence of the IGF2R STR and SNP genotypes on the milk traits, we used the AI-REML (average information restricted maximum likelihood) method with repeatability, multi-trait animal model based on test-day information using DMU package. Statistical analysis revealed that the G/A genotype (P <= 0.01) was associated with milk and protein yield, lactose content and somatic cell count (SCC) in Polish HF cows. TG(n) (29/22, 28/29, 28/22, 28/28) genotypes were associated with high values for milk, (28/22, 28/23) with protein and fat yield, (25/20) with lactose content, and (29/33, 28/28) with low SCC. We suggest that the IGF2R gene polymorphisms could be useful genetic markers for dairy production traits in cattle.

• 出版日期2018-5