A Positron Emission Tomography Study Examining The Dopaminergic Activity of Armodafinil in Adults Using [C-11]Altropane and [C-11]Raclopride

作者：Spencer Thomas J^*; Madras Bertha K; Bonab Ali A; Dougherty Darin D; Clarke Allison; Mirto Tara; Martin Jessica; Fischman Alan J

来源：Biological Psychiatry, 2010, 68(10): 964-970.

DOI：10.1016/j.biopsych.2010.08.026

• ADHD
• neurochemical imaging
• PET imaging pharmacokinetics stimulants
• substance abuse

Background Armodafinil prescribed principally to treat narcolepsy is undergoing assessment of therapeutic potential for other neuropsychiatric disorders and medical conditions The neurochemical substrates and mechanisms of armodafinil are unresolved We investigated the hypothesis that armodafinil enhances wakefulness by modulating the activities of the dopamine transporter (DAT) With positron emission tomography imaging we determined DAT occupancy and changes in extracellular dopamine by armodafinil in vivo
Methods Twelve subjects were enrolled Plasma armodafinil levels were obtained In vivo armodafinil occupancy of the DAT in striatum was detected by [C-11]altropane and changes in extracellular dopamine were detected by indirect displacement of [C-11]raclopride in human subjects at different times after drug administration
Results Armodafinil (100 mg by mouth [PO]) occupied striatal DAT (34 0 +/- 90% at 1 hour 404 +/- 95% at 25 hours n = 6) and 250 mg occupied striatal DAT (60 5 +/- 74% at 1 hour, 652 +/- 61% at 25 hours n = 6) In addition armodafinil was associated with changes in extracellular dopamine (17 8 +/- 30 1% [100 mg PO] and 70 +/- 86% [250 mg PO] at 2 5 hours n = 6)
Conclusions Occupancy of the DAT and changes in extracellular dopamine in vivo further implicates the actions of armodafinil on DAT as a potential candidate for its therapeutic improvement of wakefulness and other conditions

• 出版日期2010-11-15