A novel method for the synthesis of pyrimido[1,2-a]benzimidazoles

作者：Vandyshev Dmitriy Yu^*; Shikhaliev Khidmet S; Kokonova Anna V; Potapov Andrei Yu; Kolpakova Maria G; Sabynin Artem L; Zubkov Fedor I

来源：Chemistry of Heterocyclic Compounds, 2016, 52(7): 493-497.

DOI：10.1007/s10593-016-1914-7

• N-arylitaconimides
• 1,2-diaminobenzimidazole
• methypyrrolidine-2,5-dione
• pyrimido[1,2-a]benzimidazole
• polynucleophiles

Condensation of 1,2-diaminobenzimidazole with N-arylitaconimides was studied. It was found that 2-(10-amino-N-aryl-2-oxo-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazol-3-yl)acetamides were formed in the course of this reaction upon brief heating to reflux of the reagent mixture in 2-propanol in the presence of catalytic amounts of acetic acid.

• 出版日期2016-7