Association of polymorphisms in the estrogen receptor beta (ESR2) with unexplained recurrent spontaneous abortion (URSA) in Chinese population

作者：Hu, Jingjing; Wang, Jing; Xiang, Huifeng; Li, Zelian; Wang, Binbin; Cao, Yunxia^*; Ma, Xu

来源：Journal of Maternal-Fetal and Neonatal Medicine, 2012, 25(9): 1727-1729.

DOI：10.3109/14767058.2012.663021

• Estrogen receptor beta gene
• estrogen receptor beta
• recurrent spontaneous abortion
• single nucleotide polymorphism

Objectives: To investigate the association of 1082G > A(RsaI) (rs1256049) and 1730A > G(AluI) (rs4986938) single nucleotide polymorphisms(SNPs), respectively - located on estrogen receptor beta (ESR2) gene with recurrent spontaneous abortion (RSA) in Chinese population. Methods: The study group consisted of 196 patients with RSA and 182 fertile women as control. Two functional polymorphisms 1082G > A (a silent mutation in exon 5) and 1730A > G (3' nontranslated region of the exon 8) of ESR2 were studied by association analysis. Results: There were no significant differences between ESR2 gene polymorphisms and RSA (chi(2) = 1.793, P = 0.408; chi(2) = 1.432, P = 0.489, respectively). Conclusion: The present data indicate that the studied SNPs on ESR2 gene may not be associated with RSA in Chinese population.

• 出版日期2012-9
• 单位国家卫生计生委科学技术研究所; 安徽医科大学