Adolescent Idiopathic Scoliosis May Not Be Associated with Brain Abnormalities

作者：Lee Jung Sub; Kim Seong Jang^*; Suh Kuen Tak; Kim In Joo; Kim Yong Ki

来源：Acta Radiologica, 2009, 50(8): 941-946.

DOI：10.1080/02841850903104161

• AIS
• (18)F-FDG-PET
• SPAM
• SPM

Background: The etiology of adolescent idiopathic scoliosis (AIS) is uncertain and multifactorial. Recently, regional brain volume differences have been reported in the pathogenesis of AIS.
Purpose: To examine cerebral glucose metabolism using (18)F-fluorodeoxyglucose (FDG) brain positron emission tomography (PET) in patients with AIS and in gender-matched healthy control subjects.
Material and Methods: Twenty-six right-handed AIS patients (six male, 20 female; mean age 14.6 /-2.22 years, range 11-18 years) were prospectively recruited for this study. Fourteen young adults (three male, 11 female; mean age 27 /-1.54 years, range 25-29 years) were included as a control group. Statistical parametric mapping (SPM) was used to determine cerebral glucose metabolism. Statistical probabilistic anatomical mapping (SPAM) was used to investigate the metabolic differences between AIS and normal control subjects with respect to previously reported brain areas.
Results: SPM analysis showed no voxels with differing cerebral glucose metabolism in AIS patients. SPAM analysis revealed no significant differences between AIS and normal control subjects.
Conclusion: SPM and SPAM analyses showed no statistically significant differences in cerebral glucose metabolism between AIS and normal control subjects. These results may suggest that there is no relationship between AIS and brain abnormalities.

• 出版日期2009