科研之友
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摘要
As newly found cellular stress response, the mitochondrial unfolded protein response (UPRmt) is associated with the pathological process of aging, cancer and neurodegenerative diseases. To maintain mitochondrial protein homeostasis, cell will inspire UPRmt program by activating the transcription of mitochondrial chaperones and proteases encoded by nuclear DNA. Exploring the mechanisms of UPRmt is essential for understanding the pathological process of aging and mitochondria-related diseases. In this review, we focus on various inducers of UPRmt, the different mechanisms of UPRmt, the regulatory factors, and relationship with aging, immunity and other diseases in C. elegans and mammalian cells to provide new theoretical basis and therapeutic target for these diseases.
- 出版日期2017-6
- 单位河北师范大学
