A novel, high-yielding approach to a chiral inducer: (2R,3R)-1, 4-dimethoxy-1,1,4,4-tetraphenylbutane-2,3-diol

作者:Hu Xiaoyun*; Shan Zixing; Song Shaojun
来源:Tetrahedron: Asymmetry , 2014, 25(6-7): 503-506.
DOI:10.1016/j.tetasy.2014.01.018

摘要

A new method for preparing (2R,3R)-1,4-dimethoxy-1,1,4,4-tetraphenylbutane-2,3-diol in high yield based on selective 2,3-spiroboration of (2R,3R)-1,1,4,4-tetraphenylbutanetetraol has been developed. It avoids traditional oxidation and reduction steps, and provides a simplified, more straightforward, and high-yielding synthesis of the title compound.