An Efficient Synthesis of Bridged Heterocycles from an Ir(I) Bis-Amination/Ring-Closing Metathesis Sequence

作者：Brawn Ryan A^*; Guimaraes Cristiano R W; McClure Kim F; Liras Spiros

来源：Organic Letters, 2012, 14(18): 4802-4805.

DOI：10.1021/ol302108m

The amination of bis-allylic imidates using an Iridium(I) catalyst leads to the efficient formation of 2,6-divinyl heterocycles. Careful screening of amines, solvents, and conditions has led to the discovery of a system that favors formation of the desired cis products with synthetically useful levels of diastereoselectivity, and these results are further explained by computer based transition state energy calculations. Exposure of the heterocycles to ring-closing metathesis catalysts leads to the desired bridged heterocyclic systems.

• 出版日期2012-9-21