All serotypes of dengue virus induce HLA-A2 major histocompatibility complex class I promoter activity in human liver cells

作者：Othman Shatrah; Rahman Noorsaadah A; Yusof Rohana^*

来源：Transactions of the Royal Society of Tropical Medicine and Hygiene, 2010, 104(12): 806-808.

DOI：10.1016/j.trstmh.2010.07.004

• Dengue virus
• Flavivirus
• MHC class I
• Promoter
• Regulatory elements
• Host response

In contrast to many viruses that escape the host's immune responses by suppressing the major histocompatibility complex (MHC) class I pathway, flaviviruses have been shown to up-regulate the cell surface expression of MHC class I complex. The mechanism by which dengue virus (DV) achieves this up-regulation remains unclear. Our investigation on the HLA-A2 gene in human liver cells demonstrated that all four serotypes of dengue virus, DV1 to DV4, resulted in variable degrees of promoter induction. This illustrates the importance of MHC class I transcription regulation in primary infections by different DV serotypes that may have even greater impact in secondary infections, associated with increased disease severity.

• 出版日期2010-12