Asymmetric synthesis of syn-alpha-substituted beta-amino ketones by using sulfinimines and prochiral weinreb amide enolates

作者：Davis Franklin A^*; Song Minsoo

来源：Organic Letters, 2007, 9(12): 2413-2416.

DOI：10.1021/ol0708166

syn-alpha-Substituted beta-amino Weinreb amides are new chiral building blocks for asymmetric synthesis of syn-alpha-substituted beta-amino acids, aldehydes, and ketones and are prepared by addition of prochiral lithium enolates of Weinreb amides to sulfinimines (N-sulfinyl imines).

• 出版日期2007-6-7