Associations between vitamin D status in infants and blood lipids, body mass index and waist circumference

作者：Arnberg K^*; Ostergard M; Madsen A L; Krarup H; Michaelsen K F; Molgaard C

来源：Acta Paediatrica, 2011, 100(9): 1244-1248.

DOI：10.1111/j.1651-2227.2011.02273.x

• 25-hydroxyvitamin D
• Body mass index
• Infants
• Lipids
• Waist circumference

Aim: To study the relationships between 25-hydroxyvitamin D status and blood lipids, insulin, glucose, body mass index and waist circumference in infants.
Methods: In a cross-sectional study, 255 infants aged 9 months with a blood sample for 25-hydroxyvitamin D were examined. Plasma 25-hydroxyvitamin D concentrations were analysed by chemiluminescent immunoassay. Associations between plasma 25-hydroxyvitamin D and high-density lipoprotein (HDL), low-density lipoprotein, total cholesterol, triglycerides, insulin, glucose, body mass index and waist circumference were analysed.
Results: Mean plasma 25-hydroxyvitamin D was 77.2 +/- 22.7 nM. At the time of examination, 97% received vitamin D supplementation. 25-Hydroxyvitamin D was negatively associated with HDL (p = 0.003), cholesterol (p = 0.002) and triglycerides (p = 0.010) in multivariate analysis controlled for gender, season, body mass index, length, birth weight and breastfeeding. There were no associations between 25-hydroxyvitamin D and glucose or insulin (all p > 0.05). 25-hydroxyvitamin D was negatively associated with body mass index (p = 0.005) and waist circumference (p = 0.002) controlled for gender, season, breastfeeding, birth weight and length.
Conclusion: Vitamin D status is negatively associated with blood lipids, body mass index and waist circumference in infants where nearly all received vitamin D supplements. Whether this has long-term health effects remains to be elucidated.

• 出版日期2011-9