Neuropathology of Sleep Disorders: A Review

作者:Hauw Jean Jacques*; Hausser Hauw Chantal; De Girolami Umberto; Ha**oun Dominique; Seilhean Danielle
来源:Journal of Neuropathology and Experimental Neurology, 2011, 70(4): 243-252.
DOI:10.1097/NEN.0b013e318211488e

摘要

Sleep disorders are important manifestations of neurodegenerative diseases and sometimes are clinically evident well before the onset of other neurological manifestations. This review addresses the neuroanatomical basis and the mechanisms of sleep regulation in humans in relation to the neuropathology of entities associated with sleep disturbances in selected diseases, including Alzheimer disease, progressive supranuclear palsy, Lewy body disorders, multiple-system atrophy, and fatal familial insomnia. This includes abnormalities of circadian rhythm, insomnia, narcolepsy, rapid eye movements sleep behavior disorders, and excessive daytime sleepiness.

  • 出版日期2011-4